Article

Network medicine-based epistasis detection in complex diseases: ready for quantum computing

2023-11-09

Abstract excerpt

Most heritable diseases are polygenic. To comprehend the underlying genetic architecture, it is crucial to discover the clinically relevant epistatic interactions (EIs) between genomic single nucleotide polymorphisms (SNPs) 1–3 . Existing statistical computational methods for EI detection are mostly limited to pairs of SNPs due to the combinatorial explosion of higher-order EIs. With NeEDL ( ne twork-based e pi...

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Literature Corpus work: f4f7df2f-acbc-5ab6-8241-f0cca235c211
DOI: 10.1101/2023.11.07.23298205

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