Article

Cardiomyocyte hypertrophy co-localizes with accumulation of hyaluronan in cMyBPC <sup>+/-</sup> mice hearts

2026-02-02

Abstract excerpt

Hypertrophic cardiomyopathy (HCM) is a genetic heart disease characterized by left ventricular hypertrophy. Mutations in genes for sarcomere proteins, e.g. in cardiac myosin-binding protein C (cMyBPC), cause symptoms like heart failure and sudden cardiac death. In HCM, the heart utilizes high amounts of glucose. Increased glucose metabolism creates intermediates for hyaluronan (HA) synthesis, resulting in HA accum...

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Literature Corpus work: f4e6c2c9-00be-5192-aadb-1690378a1f96
DOI: 10.64898/2026.01.30.702716

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