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Article

Integrative Proteomic and Metabolomic Analysis Reveals Metabolic Phenotype in Mice With Cardiac-Specific Deletion of Natriuretic Peptide Receptor A.

Molecular & cellular proteomics : MCP - 1 Jan 2021

Chang Pan, Niu Yan, Zhang Xiaomeng, Zhang Jing, Wang Xihui, Shen Xi, Chen Baoying, Yu Jun

Abstract excerpt

Atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) are important biological markers and cardiac function regulators. Natriuretic peptide receptor A (NPRA) binds to an ANP or BNP ligand and induces transmembrane signal transduction by elevating the intracellular cyclic guanosine monophosphate (cGMP) levels. However, the metabolic phenotype and related mechanisms induced by NPRA deletion remain...

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Identifiers

PMID: 33812089
DOI: 10.1016/j.mcpro.2021.100072
PMCID: PMC8131926

Genes

F2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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