Article
Developmental cardiac hypertrophy in a mouse model of prolidase deficiency.
Birth defects research. Part A, Clinical and molecular teratology - 1 Apr 2011
Jung Seungwoo, Silvius Derek, Nolan Katherine A, Borchert Gregory L, Millet Yoann H, Phang James M, Gunn Teresa M
Abstract excerpt
BACKGROUND: Hypertrophic cardiomyopathy, characterized by thickened ventricular walls and reduced ventricular chamber volume, is a common cause of sudden cardiac death in young people. Most inherited forms result from mutations in genes encoding sarcomeric proteins. METHODS: Histologic analysis identified embryonic cardiac hypertrophy in dark-like mutant mice. BrdU analysis was performed to measure proliferation...
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