Article

Glial expression of <i>Drosophila UBE3A</i> causes spontaneous seizures modulated by 5-HT signaling

2024-02-09

Abstract excerpt

Misexpression of the E3 ubiquitin ligase UBE3A is thought to contribute to a range of neurological disorders. In the context of Dup15q syndrome, excess genomic copies of UBE3A is thought to contribute to the autism, muscle tone and spontaneous seizures characteristic of the disorder. In a Drosophila model of Dup 15q syndrome, it was recently shown glial-driven expression of the UBE3A ortholog dube3a led to a...

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Literature Corpus work: f4d514ed-7501-573c-aa45-462318a682ba
DOI: 10.1101/2024.02.08.579543

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