Article
GABAergic neuronal dysfunction underlies tremor in spinocerebellar ataxia 3.
Disease models & mechanisms - 1 Oct 2025
Banerjee Animesh, Chatterjee Moumita, Tan Kah Junn, Tay Shermaine, Duan Kaibo, Andiappan Anand Kumar, Howland Shanshan Wu, Aso Yoshinori, Aw Sherry Shiying
Abstract excerpt
Tremor is a common movement disorder associated with several neurodegenerative diseases, yet its mechanisms are not well understood. Using a machine-learning method, Feature Learning-based Leg segmentation and Tracking (FLLIT), we previously characterised gait and tremor signatures in a Drosophila model for spinocerebellar ataxia 3 (SCA3) and found them to be analogous to those in human SCA3. Here, we carried out...
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