Article

Neuronal microscale biophysical instability mediates macroscale network dynamics shaping pathological manifestations

2026-01-22

Abstract excerpt

Subtle changes in membrane excitability may contribute to neurological disease, but disease-relevant dynamical signatures that generalize across models remain poorly defined. Here, we quantified variability in action potential initiation in Drosophila neurons expressing tauopathy- or epilepsy-associated mutations and in human iPSC-derived neurons from patients with Alzheimer’s disease or epilepsy. Across these mo...

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Literature Corpus work: 4e597560-880f-5f94-87f5-65d8a4556316
DOI: 10.64898/2026.01.20.697254

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