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Automated identification of ataxia and convulsions in hyperexcitable <i>Shudderer</i> mutants of the <i>Drosophila</i> sodium channel gene <i>paralytic</i>

2025-10-22

Abstract excerpt

Drosophila carrying the Shudderer ( Shu ) allele of the voltage-gated Na + gene paralytic display spontaneous convulsions and immobilization phenotypes that are exacerbated by high temperature. To automate identification of these aberrant behaviors in Shu mutants, we trained a machine-learning classifier on a manually annotated dataset. The system reliably classified walking activity and immobilization period...

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Literature Corpus work
9b7d3f44-8d8f-5b7a-8aa5-b07c6a9117dd
DOI
10.1101/2025.10.22.683992
Open publication

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Automated identification of ataxia and convulsions in hyperexcitable <i>Shudderer</i> mutants of the <i>Drosophila</i> sodium channel gene <i>paralytic</i>DOI 10.1101/2025.10.22.683992
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