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Biomarkers for Homologous Recombination Deficiency in Cancer

10 Apr 2018

Abstract excerpt

Defective DNA repair is a common hallmark of cancer. Homologous recombination is a DNA repair pathway of clinical interest due to the sensitivity of homologous recombination-deficient cells to poly-ADP ribose polymerase (PARP) inhibitors. The measurement of homologous recombination deficiency (HRD) in cancer is therefore vital to the appropriate design of clinical trials incorporating PARP inhibitors. However,...

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PMID: 29788099
DOI: 10.1093/jnci/djy085

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