Article

P66 is a bacterial mimic of CD47 that binds the anti-phagocytic receptor SIRPα and facilitates macrophage evasion by <i>Borrelia burgdorferi</i>

2024-04-30

Abstract excerpt

<h4>Summary Paragraph</h4> Innate immunity, the first line of defense against pathogens, relies on efficient elimination of invading agents by phagocytes. In the co-evolution of host and pathogen, pathogens developed mechanisms to dampen and evade phagocytic clearance. Here, we report that bacterial pathogens can evade clearance by macrophages through mimicry at the mammalian anti-phagocytic “don’t eat me” signal...

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Literature Corpus work: f4ce7189-efb2-593d-b4de-940770fb7090
DOI: 10.1101/2024.04.29.591704

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