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Article

CD46 accelerates macrophage-mediated host susceptibility to meningococcal sepsis in a murine model.

European journal of immunology - 1 Jan 2017

Wang Xiao, Zhang Ding, Sjölinder Mikael, Wan Yi, Sjölinder Hong

Abstract excerpt

CD46, a membrane cofactor expressed on all nucleated human cells, plays an essential role in suppressing autoimmune reactions and protecting host cells from complement-mediated attack. Human transgenic CD46 homozygous mice (CD46+/+ ) are prone to lethal sepsis upon infection with Neisseria meningitidis (N. meningitidis). However, the underlying mechanisms are poorly understood. Here, we determined thatCD46+/+...

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Source

Identifiers

PMID: 27794168
DOI: 10.1002/eji.201646397

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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