Article

Active learning-guided optimization of cell-free biosensors for lead testing in drinking water

2025-08-20

Abstract excerpt

Point-of-use diagnostics based on allosteric transcription factors (aTFs) are promising tools for environmental monitoring and human health. However, biosensors relying on natural aTFs rarely exhibit the sensitivity and selectivity needed for real-world applications, and traditional directed evolution struggles to optimize multiple biosensor properties at once. To overcome these challenges, we develop a multi-obje...

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Literature Corpus work: f4b9f813-2a90-56e0-a93e-a044f04f6e5e
DOI: 10.1101/2025.08.20.671382

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