Article

A general strategy to engineer high-performance mammalian Whole-Cell Biosensors

2024-02-29

Abstract excerpt

Transcription-based whole-cell biosensors (WCBs) are cells engineered with an analyte-responsive promoter driving the transcription of a reporter gene. WCBs can sense and report on bioactive molecules (analytes) relevant to human health. Designing an analyte-sensitive promoter requires a cumbersome trial-and-error approach and usually results in biosensors with poor performance. Here, we integrated Synthetic Biolo...

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Literature Corpus work: 68b73236-0579-587a-b565-cc4468fd4589
DOI: 10.1101/2024.02.28.582526

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