Article

Hedgehog-Hippo pathway interactions promote T cell exclusion from the tumor microenvironment in basal cell carcinoma

2024-07-07

Abstract excerpt

Basal cell carcinoma (BCC) is the most common non-melanoma skin cancer driven primarily by genetic activation of the Hedgehog/GLI (HH/GLI) signaling pathway. BCC also displays a high mutational burden, with frequent co-occurrence of mutations in the TP53, NOTCH, N-MYC, and Hippo/YAP pathways, though the impact of these mutations on HH/GLI-driven tumorigenesis remains poorly understood. This study examines the inte...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f48e2384-86f4-540d-9973-b9c52e9c16d5
DOI: 10.1101/2024.07.07.602398

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Hedgehog-Hippo pathway interactions promote T cell exclusion from the tumor microenvironment in basal cell carcinomaDOI 10.1101/2024.07.07.602398Read

YAP‐TEAD signaling promotes basal cell carcinoma development via a c‐JUN/AP1 axisSemantic proximity Read

The transcriptional landscape analysis of basal cell carcinomas reveals novel signalling pathways and actionable targetsSemantic proximity Read

Novel Approaches in Non-Melanoma Skin Cancers—A Focus on Hedgehog Pathway in Basal Cell Carcinoma (BCC)Semantic proximity Read

Recent Advances in Signaling Pathways Comprehension as Carcinogenesis Triggers in Basal Cell CarcinomaSemantic proximity Read

Oncogenic GLI1 and STAT1/3 activation drives immunosuppressive tryptophan/kynurenine metabolism via synergistic induction of IDO1 in skin cancer cellsSemantic proximity Read

Distinct transcriptomic landscapes of cutaneous basal cell carcinomas and squamous cell carcinomasSemantic proximity Read

Genetic and functional interaction network analysis reveals global enrichment of regulatory T cell genes influencing basal cell carcinoma susceptibility.Semantic proximity Read

Basal cell carcinomas in mice arise from hair follicle stem cells and multiple epithelial progenitor populations.Semantic proximity Read

[Cutaneous epithelial tumors. Molecular biology and pathogenesis-based therapy].Semantic proximity Read

Immunoregulatory Molecule B7-H1 (CD274) Contributes to Skin CarcinogenesisSemantic proximity Read

Understanding the Molecular Genetics of Basal Cell Carcinoma.Semantic proximity Read

Tumor Stroma–Derived Wnt5a Induces Differentiation of Basal Cell Carcinoma of Ptch -Mutant Mice via CaMKIISemantic proximity Read