Tumor Stroma–Derived Wnt5a Induces Differentiation of Basal Cell Carcinoma of Ptch -Mutant Mice via CaMKII

Abstract excerpt

Basal cell carcinoma (BCC) is the most common skin tumor in humans. Although BCCs rarely metastasize, they can cause significant morbidity due to local aggressiveness. Approximately 20% of BCCs show signs of spontaneous regression. The understanding of molecular events mediating spontaneous regression has the potential to reduce morbidity of BCC and, potentially, other tumors, if translated into tumor therapies....

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