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Novel proteomic subtypes of frailty with distinct molecular patterns and prognosis.

Maturitas - 1 Mar 2026

Xu Zhenyi, Wang Ce, Wang Jiaofeng, Chen Jie, Wang Xiaojun, Bao Zhijun, Zhang Yan

Abstract excerpt

OBJECTIVES: The frailty phenotype has limitations in capturing the biological heterogeneity of the condition. Our study identified subtypes of frailty based on proteomics and examined their associations with several adverse outcomes. METHOD: The study included 1513 frail individuals and 29,339 non-frail individuals from the UK Biobank and analyzed 2920 proteins. Unsupervised K-means clustering was applied to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 41604822
DOI: 10.1016/j.maturitas.2026.108851

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