Article

Aging alters tumor cell - T cell crosstalk to promote breast cancer progression

2025-11-17

Abstract excerpt

Age is a dominant risk factor for all major breast cancer subtypes. However, the mechanisms by which aging influences tumor development remain unclear. Using a novel mouse model whereby breast cancer is induced in situ in young and old wild-type mice via intraductal delivery of a lentivirus encoding the HER2/neu oncogene, we found that old mice exhibited a higher oncogene-induced tumor burden than young mice. Ol...

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Literature Corpus work: 81ace7f0-3dc2-5011-a1f5-71940c4d4be5
DOI: 10.1101/2025.11.17.688754

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