Article

A new test suggests that balancing selection maintains hundreds of non-synonymous polymorphisms in the human genome

2021-02-08

Abstract excerpt

The role that balancing selection plays in the maintenance of genetic diversity remains unresolved. Here we introduce a new test, based on the McDonald-Kreitman test, in which the number of polymorphisms that are shared between populations is contrasted to those that are private at selected and neutral sites. We show that this simple test is robust to a variety of demographic changes, and that it can also give a d...

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Literature Corpus work: f4613530-07ca-5d19-b0e5-b14efdbd3704
DOI: 10.1101/2021.02.08.430226

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