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Article

Hallmarks of acute kidney injury: molecular endotypes, precision phenotyping, and phase-adapted therapy.

EBioMedicine - 1 Sept 2026

Hu Hongtu, Liu Zikang, Ji Rui, Huang Yinghui

Abstract excerpt

Acute kidney injury (AKI) is a heterogeneous syndrome for which creatinine and urine output incompletely represent underlying biology and temporal evolution. We organise AKI pathophysiology into four interconnected dimensions: initiation and effector injury; cell fate and immune microenvironment; repair and outcome determination; and systemic integration. These dimensions encompass microvascular and metabolic...

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Topics

Humans
Acute Kidney Injury
Biomarkers
Phenotype
Animals

Source

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 42603515
DOI: 10.1016/j.ebiom.2026.106436
PMCID: PMC13499454

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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