Inducible gene switches with memory in human T cells for cellular immunotherapy

Abstract excerpt

Cell-based therapies that employ engineered T cells—including the expression of chimeric antigen receptors (CARs)—to target cancer cells have demonstrated promising responses in clinical trials. However, engineered T cell responses must be regulated to prevent severe side effects such as cytokine storms and off-target responses. Here we present a class of recombinase-based gene circuits that will enable inducible...

Topics

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• CAR-T cell therapy research
• Carcinogenesis
• CRISPR-Associated Protein 9
• CRISPR-Cas Systems
• Gene Editing
• Gene Regulatory Networks
• Nanowire Synthesis and Applications
• Viral Infectious Diseases and Gene Expression in Insects

Identifiers and source

Literature Corpus work

cf58a70a-d25e-5b6c-8486-40e143199d79

DOI

10.1101/346783