Article

High-affinity nanobodies as tools for structural and functional studies on mammalian Arc

2021-12-16

Abstract excerpt

Activity-regulated cytoskeleton-associated protein (Arc) is a multidomain protein of retroviral origin with a vital role in the regulation of synaptic plasticity and memory formation in mammals. However, the mechanistic and structural basis of Arc function is little understood. Arc has an NTD involved in membrane binding and a CTD which binds postsynaptic protein ligands. In addition, the NTD and CTD both function...

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Literature Corpus work: f421065e-323f-5a69-bed3-a82d7d010530
DOI: 10.1101/2021.12.16.472929

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