Article

Key Regulatory Elements of the TGFβ-LRRC15 Axis Predict Disease Progression and Immunotherapy Resistance Across Cancer Types

2024-11-25

Abstract excerpt

<h4>ABSTRACT</h4> Transforming growth factor-beta (TGFβ) has dual roles in cancer, initially suppressing tumors but later promoting metastasis and immune evasion. Efforts to inhibit TGFβ have been largely unsuccessful due to significant toxicity and indiscriminate immunosuppression. Leucine-rich repeat-containing protein 15 (LRRC15) is a TGFβ-regulated antigen expressed by mesenchymal-derived cancer cells and can...

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Literature Corpus work: f417728f-df1a-5514-a87f-2ec725d4ee8f
DOI: 10.1101/2024.11.22.624939

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