Article

CREB5 promotes immunotherapy resistance via tumor-intrinsic collagen matrix deposition

2025-04-26

Abstract excerpt

Treatment with immune checkpoint inhibitors induces remarkable clinical responses in several cancer types. However, most cancer patients fail to respond to immunotherapy, and patients who initially respond often exhibit acquired resistance. Understanding the universe of immune evasion strategies will enable design of more effective immunotherapies. Here, we identify genes that drive immune evasion using genome-sca...

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Literature Corpus work: e5557dec-62ee-5fcc-945a-f8641ced23d3
DOI: 10.1101/2025.04.22.649109

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