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Article

Statistical control of structural networks with limited interventions to minimize cellular phenotypic diversity represented by point attractors.

Scientific reports - 18 Apr 2023

Kim Jongwan, Hopper Corbin, Cho Kwang-Hyun

Abstract excerpt

The underlying genetic networks of cells give rise to diverse behaviors known as phenotypes. Control of this cellular phenotypic diversity (CPD) may reveal key targets that govern differentiation during development or drug resistance in cancer. This work establishes an approach to control CPD that encompasses practical constraints, including model limitations, the number of simultaneous control targets, which...

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Identifiers

PMID: 37072458
DOI: 10.1038/s41598-023-33346-1
PMCID: PMC10113376

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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