Article

SARS CoV-2 nucleoprotein enhances the infectivity of lentiviral spike particles

2021-02-15

Abstract excerpt

The establishment of SARS CoV-2 spike-pseudotyped lentiviral (LV) systems has enabled the rapid identification of entry inhibitors and neutralizing agents, alongside allowing for the study of this emerging pathogen in BSL-2 level facilities. While such frameworks recapitulate the cellular entry process in ACE2+ cells, they are largely unable to factor in supplemental contributions by other SARS CoV-2 genes. To add...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f412e19b-cdd2-5b1f-a7b6-63555ee2b6e0
DOI: 10.1101/2021.02.11.430757

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

SARS CoV-2 nucleoprotein enhances the infectivity of lentiviral spike particlesDOI 10.1101/2021.02.11.430757Read

SARS CoV-2 Nucleoprotein Enhances the Infectivity of Lentiviral Spike ParticlesSemantic proximity Read

SARS-CoV-2 spike-protein D614G mutation increases virion spike density and infectivity.Semantic proximity Read

Quantifying absolute neutralization titers against SARS-CoV-2 by a standardized virus neutralization assay allows for cross-cohort comparisons of COVID-19 seraSemantic proximity Read

Cytoplasmic Tail Truncation of SARS-CoV-2 Spike Protein Enhances Titer of Pseudotyped Vectors but Masks the Effect of the D614G Mutation.Semantic proximity Read

A cell-based, spike protein binding assay highlights differences in antibody neutralising capacity for SARS-CoV-2 variantsSemantic proximity Read

Cytoplasmic tail truncation of SARS-CoV-2 Spike protein enhances titer of pseudotyped vectors but masks the effect of the D614G mutationSemantic proximity Read

Effective Screening of SARS-CoV-2 Neutralizing Antibodies in Patient Serum using Lentivirus Particles Pseudotyped with SARS-CoV-2 Spike GlycoproteinSemantic proximity Read

The Spike D614G mutation increases SARS-CoV-2 infection of multiple human cell typesSemantic proximity Read

SARS-CoV-2 protein ORF8 limits expression levels of Spike antigen and facilitates immune evasion of infected host cellsSemantic proximity Read

A pseudovirus system enables deep mutational scanning of the full SARS-CoV-2 spike.Semantic proximity Read

Naturally mutated spike proteins of SARS-CoV-2 variants show differential levels of cell entrySemantic proximity Read

Effects of Spike Mutations in SARS-CoV-2 Variants of Concern on Human or Animal ACE2-Mediated Virus Entry and NeutralizationSemantic proximity Read