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SARS CoV-2 Nucleoprotein Enhances the Infectivity of Lentiviral Spike Particles

23 Apr 2021

Abstract excerpt

The establishment of SARS CoV-2 spike-pseudotyped lentiviral (LV) systems has enabled the rapid identification of entry inhibitors and neutralizing agents, alongside allowing for the study of this emerging pathogen in BSL-2 level facilities. While such frameworks recapitulate the cellular entry process in ACE2+ cells, they are largely unable to factor in supplemental contributions by other SARS CoV-2 genes. To...

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PMID: 33968806
DOI: 10.3389/fcimb.2021.663688

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