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<i>Gemin4</i> is an essential gene in mice, and its overexpression in human cells causes relocalization of the SMN complex to the nucleoplasm

2018-01-04

Abstract excerpt

Gemin4 is a member of the Survival Motor Neuron (SMN) protein complex, which is responsible for the assembly and maturation of Sm-class small nuclear ribonucleoproteins (snRNPs). In metazoa, Sm snRNPs are assembled in the cytoplasm and subsequently imported into the nucleus. We previously showed that the SMN complex is required for snRNP import in vitro , although it remains unclear which specific components dire...

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Literature Corpus work
f3fd3891-5fad-5e40-a653-33b49c6c44f4
DOI
10.1101/242529
Open publication

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