Article

Composition of the Survival Motor Neuron (SMN) complex in <i>Drosophila melanogaster</i>

2018-11-11

Abstract excerpt

Spinal Muscular Atrophy (SMA) is caused by homozygous mutations in the human survival motor neuron 1 ( SMN1 ) gene. SMN protein has a well-characterized role in the biogenesis of small nuclear ribonucleoproteins (snRNPs), core components of the spliceosome. SMN is part of an oligomeric complex with core binding partners, collectively called Gemins. Biochemical and cell biological studies demonstrate that certain...

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Literature Corpus work: a36ea28d-ca54-5643-8586-1caeb000c1cf
DOI: 10.1101/468223

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