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Article

Gemin proteins are required for efficient assembly of Sm-class ribonucleoproteins

21 Nov 2005

Abstract excerpt

Spinal muscular atrophy (SMA) is a neurodegenerative disease characterized by loss of spinal motor neurons. The gene encoding the survival of motor neurons (SMN) protein is mutated in >95% of SMA cases. SMN is the central component of a large oligomeric complex, including Gemins2-7, that is necessary and sufficient for the in vivo assembly of Sm proteins onto the small nuclear (sn)RNAs that mediate pre-mRNA...

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PMID: 16301532
DOI: 10.1073/pnas.0508947102

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Gemin proteins are required for efficient assembly of Sm-class ribonucleoproteinsPMID 16301532Read ↗

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