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Article

Gemins modulate the expression and activity of the SMN complex

20 Apr 2005

Abstract excerpt

Reduction in the expression of the survival of motor neurons (SMN) protein results in spinal muscular atrophy (SMA), a common motor neuron degenerative disease. SMN is part of a large macromolecular complex (the SMN complex) that includes at least six additional proteins called Gemins (Gemin2-7). The SMN complex is expressed in all cells and is present throughout the cytoplasm and in the nucleus where it is...

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PMID: 15843395
DOI: 10.1093/hmg/ddi168

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