Article
Hypomorphic and hypermorphic mouse models of Fsip2 indicate its dosage-dependent roles in sperm tail and acrosome formation.
Development (Cambridge, England) - 1 Jun 2021
Fang Xiang, Gamallat Yaser, Chen Zhiheng, Mai Hanran, Zhou Pei, Sun Chuanbo, Li Xiaoliang, Li Hong, Zheng Shuxin, Liao Caihua, Yang Miaomiao, Li Yan, Yang Zeyu, Ma Caiqi, Han Dingding, Zuo Liandong, Xu Wenming, Hu Hao, Sun Ling, Li Na
Abstract excerpt
Loss-of-function mutations in multiple morphological abnormalities of the sperm flagella (MMAF)-associated genes lead to decreased sperm motility and impaired male fertility. As an MMAF gene, the function of fibrous sheath-interacting protein 2 (FSIP2) remains largely unknown. In this work, we identified a homozygous truncating mutation of FSIP2 in an infertile patient. Accordingly, we constructed a knock-in (KI)...
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