Human X chromosome exome sequencing identifies BCORL1 as contributor to spermatogenesis

Abstract excerpt

Background Infertility affects approximately 15% of couples worldwide with male infertility being responsible for approximately 50% of cases. Although accumulating evidence demonstrates the critical role of the X chromosome in spermatogenesis during the last few decades, the expression patterns and potential impact of the X chromosome, together with X linked genes, on male infertility are less well understood....

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