Article
Cell Painting predicts impact of lung cancer variants.
Molecular biology of the cell - 15 May 2022
Caicedo Juan C, Arevalo John, Piccioni Federica, Bray Mark-Anthony, Hartland Cathy L, Wu Xiaoyun, Brooks Angela N, Berger Alice H, Boehm Jesse S, Carpenter Anne E, Singh Shantanu
Abstract excerpt
Most variants in most genes across most organisms have an unknown impact on the function of the corresponding gene. This gap in knowledge is especially acute in cancer, where clinical sequencing of tumors now routinely reveals patient-specific variants whose functional impact on the corresponding genes is unknown, impeding clinical utility. Transcriptional profiling was able to systematically distinguish these...
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