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Article

Single-cell morphology encodes metastatic potential.

Science advances - 1 Jan 2020

Wu Pei-Hsun, Gilkes Daniele M, Phillip Jude M, Narkar Akshay, Cheng Thomas Wen-Tao, Marchand Jorge, Lee Meng-Horng, Li Rong, Wirtz Denis

Abstract excerpt

A central goal of precision medicine is to predict disease outcomes and design treatments based on multidimensional information from afflicted cells and tissues. Cell morphology is an emergent readout of the molecular underpinnings of a cell's functions and, thus, can be used as a method to define the functional state of an individual cell. We measured 216 features derived from cell and nucleus morphology for...

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Identifiers

PMID: 32010778
DOI: 10.1126/sciadv.aaw6938
PMCID: PMC6976289

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