Article

The regulatory landscape of optic fissure closure in the vertebrate eye

2026-02-14

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Purpose</h4> Optic fissure closure (OFC) is a critical tissue fusion event in normal eye development and its failure results in ocular coloboma (OC), an inferonasal ocular tissue defect that persists throughout life. Most OC cases lack a genetic diagnosis, reflecting limited understanding of the genes and pathways that regulate OFC. We aimed to determine if OFC gene expression is regulated...

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Literature Corpus work: f3cfca34-596c-5dcf-ae07-8831d2213f1d
DOI: 10.64898/2026.02.11.705341

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