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Deciphering the spatiotemporal transcriptional and chromatin accessibility of human retinal organoid development at the single-cell level

4 Mar 2024

Abstract excerpt

Molecular information on the early stages of human retinal development remains scarce due to limitations in obtaining early human eye samples. Pluripotent stem cell-derived retinal organoids (ROs) provide an unprecedented opportunity for studying early retinogenesis. Using a combination of single cell RNA-seq and spatial transcriptomics we present for the first-time a single cell spatiotemporal transcriptome of...

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PMID: 38510120
DOI: 10.1016/j.isci.2024.109397

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