Article

Single-cell multiomics identifies key nodes and cis-regulatory elements of the networks specifying the eye domains in zebrafish

2026-02-02

Abstract excerpt

Congenital eye malformations result from disruptions in the early developmental programs that specify and regionalize the eye primordium. Human genetics and developmental studies in animal models have identified critical regulatory nodes within the gene regulatory networks (GRNs) patterning the distinct eye domains. However, the fundamental cis-regulatory connectivity of these networks, and their dynamic behaviour...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 823955eb-5760-518f-888e-efa584d5e11b
DOI: 10.64898/2026.01.31.703039

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Single-cell multiomics identifies key nodes and cis-regulatory elements of the networks specifying the eye domains in zebrafishDOI 10.64898/2026.01.31.703039Read

Analysis of gene network bifurcation during optic cup morphogenesis in zebrafishSemantic proximity Read

A multi-omics atlas of the human retina at single-cell resolutionSemantic proximity Read

The regulatory landscape of optic fissure closure in the vertebrate eyeSemantic proximity Read

Deciphering the spatio-temporal transcriptional and chromatin accessibility of human retinal organoid development at the single cell levelSemantic proximity Read

Integration of in situ hybridization and scRNA-seq data provides a 2D topographical map of the developing retina across speciesSemantic proximity Read

Gene regulatory networks controlling temporal patterning, neurogenesis, and cell fate specification in the mammalian retinaSemantic proximity Read

Integrated annotation and analysis of genomic features reveal new types of functional elements and large-scale epigenetic phenomena in the developing zebrafishSemantic proximity Read

A conserved enhancer cluster regulates <i>efnb2</i> expression in the vertebrate dorsal retinaSemantic proximity Read

Multi-species single-cell transcriptomic analysis of ocular compartment regulonsSemantic proximity Read

Single-cell analysis of the epigenome and 3D chromatin architecture in the human retinaSemantic proximity Read

Multi-omic Analysis of Developing Human Retina and Organoids Reveals Cell-Specific Cis-Regulatory Elements and Mechanisms of Non-Coding Genetic Disease RiskSemantic proximity Read

Deconvolution of single-cell multi-omics layers reveals regulatory heterogeneitySemantic proximity Read