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Article

Regional Gene Expression Profile Comparison Reveals the Unique Transcriptome of the Optic Fissure

6 Dec 2018

Abstract excerpt

Purpose: The optic fissure (OF) is a transient opening in the ventral optic cup (OC) that acts as a passage for blood vessels and retinal ganglion cell axons during early eye development. Failure to close the OF is the developmental basis for uveal coloboma, a congenital blinding eye disease that significantly contributes to childhood blindness. Genes specifically expressed in the OF region may play important...

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PMID: 30521666
DOI: 10.1167/iovs.18-23962

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