Article

Multi-omic Analysis of Developing Human Retina and Organoids Reveals Cell-Specific Cis-Regulatory Elements and Mechanisms of Non-Coding Genetic Disease Risk

2021-08-02

Abstract excerpt

<h4>SUMMARY</h4> Cis-regulatory elements (CREs) play a critical role in the development, maintenance, and disease-states of all human cell types. In the human retina, CREs have been implicated in a variety of inherited retinal disorders. To characterize cell-class-specific CREs in the human retina and elucidate their potential functions in development and disease, we performed single-nucleus (sn)ATAC-seq and snRN...

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Literature Corpus work: 5e9bf021-5159-5354-aaf6-2a825c1b11dc
DOI: 10.1101/2021.07.31.454254

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