Article

Long-term single-molecule Ca <sup>2+</sup> flux recordings reveal mode-switching regulation of Ca <sup>2+</sup> -ATPases

2026-01-31

Abstract excerpt

Calcium (Ca²⁺) is a universal second messenger that governs processes ranging from muscle contraction and secretion to gene expression and cell fate. Ca²⁺-ATPases establish and maintain steep Ca²⁺ gradients across intracellular membranes, yet how regulatory inputs modulate the underlying single-pump Ca²⁺ currents has remained inaccessible. Here we develop a non-saturating, self-regenerating single-vesicle assay th...

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Literature Corpus work: f3cd9d36-59bc-542e-bb65-bfca7efb9c9f
DOI: 10.64898/2026.01.28.701947

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Long-term single-molecule Ca <sup>2+</sup> flux recordings reveal mode-switching regulation of Ca <sup>2+</sup> -ATPasesDOI 10.64898/2026.01.28.701947Read

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