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Article

Cooperative setting for long-range linkage of Ca(2+) binding and ATP synthesis in the Ca(2+) ATPase.

Biophysical journal - 1 Nov 2002

Inesi Giuseppe, Zhang Zhongsen, Lewis David

Abstract excerpt

High-affinity and cooperative binding of two Ca(2+) per ATPase (SERCA) occurs within the membrane-bound region of the enzyme. Direct measurements of binding at various Ca(2+) concentrations demonstrate that site-directed mutations within this region interfere selectively with Ca(2+) occupancy of either one or both binding sites and with the cooperative character of the binding isotherms. A transition associated...

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Identifiers

PMID: 12414670
DOI: 10.1016/S0006-3495(02)75247-8
PMCID: PMC1302322

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