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Mitochondria and Their Role in Human Reproduction

11 Oct 2019

Abstract excerpt

Genetic defects of the mitochondrial genome can be especially devastating to patients; moreover, attention on human mitochondrial disorders has grown remarkably in recent years. Mitochondrial DNA (mtDNA) is maternally inherited in most eukaryotes, with paternal mtDNA being eliminated from the embryo through a variety of mechanisms. Consequently, mtDNA mutations acquired in a woman's germline can impair fertility...

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PMID: 31603716
DOI: 10.1089/dna.2019.4807

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