Article

ALS-associated FUS mutation reshapes the RNA and protein composition of Stress Granules

2023-09-11

Abstract excerpt

<h4>ABSTRACT</h4> Stress Granules (SG) formation is a cellular protection mechanism, constituting a storage for untranslated mRNAs and RNA-binding proteins (RBPs); however, these condensates can turn into pathological aggregates, related to the onset of neurodegenerative diseases like Amyotrophic Lateral Sclerosis (ALS). This transition towards cytotoxic inclusions is triggered by ALS-causative mutations in the R...

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Literature Corpus work: 676f2040-c601-5982-9797-2d5c7f45e9d3
DOI: 10.1101/2023.09.11.557245

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