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Article

Stress granules in the spinal muscular atrophy and amyotrophic lateral sclerosis: The correlation and promising therapy.

Neurobiology of disease - 1 Aug 2022

Hu LiDan, Mao Shanshan, Lin Li, Bai Guannan, Liu Bingjie, Mao Jianhua

Abstract excerpt

Increasing genetic and biochemical evidence has broadened our view of the pathomechanisms that lead to Spinal muscular atrophy (SMA) and Amyotrophic lateral sclerosis (ALS), two fatal neurodegenerative diseases with similar symptoms and causes. Stress granules are dynamic cytosolic storage hubs for mRNAs in response to stress exposures, that are evolutionarily conserved cytoplasmic RNA granules in somatic cells....

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PMID: 35568100
DOI: 10.1016/j.nbd.2022.105749

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