Article

FH-like protein 1-Y402H mutation promoted microglial synapse phagocytosis and cognitive impairment in Alzheimer's disease model

2023-11-08

Abstract excerpt

<h4>Background: </h4> Studies demonstrated that the complement system was involved in the pathogenesis of Alzheimer’s disease (AD). A genetic screening study in a Chinese cohort identified that two single nucleotide polymorphisms (SNPs) of the complement regulator Factor H (CFH) rs1061170 (Y402H) and rs800292 (V62I) were robustly associated with AD. FH-like protein 1 (FHL-1) is a short alternative splicing derived...

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Literature Corpus work: f3976a5f-6c24-50db-9d11-a8e0bee53965
DOI: 10.21203/rs.3.rs-3541964/v1

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