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Article

Function and Dysfunction of Complement Factor H During Formation of Lipid-Rich Deposits

8 Dec 2020

Abstract excerpt

Complement-mediated inflammation or dysregulation in lipid metabolism are associated with the pathogenesis of several diseases. These include age-related macular degeneration (AMD), C3 glomerulonephritis (C3GN), dense deposit disease (DDD), atherosclerosis, and Alzheimer's disease (AD). In all these diseases, formation of characteristic lipid-rich deposits is evident. Here, we will discuss molecular mechanisms...

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PMID: 33363547
DOI: 10.3389/fimmu.2020.611830

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