Article

Pervasive polygenicity of complex traits inflates false positive rates in transcriptome-wide association studies

2023-10-20

Abstract excerpt

Transcription-wide association studies (TWAS) and related methods (xWAS) have been widely adopted in genetic studies to understand molecular traits as mediators between genetic variation and disease. However, the effect of polygenicity on the validity of these mediator–trait association tests has largely been overlooked. Given the widespread polygenicity of complex traits, it is necessary to assess the validity an...

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Literature Corpus work: f390a5b7-0e28-5aa4-a5e3-4e5ed69d89cb
DOI: 10.1101/2023.10.17.562831

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