Article

Osteocalcin induces phosphorylation of FOXO1 in human beta-cells and restores insulin expression under hyperglycemic conditions

2025-06-13

Abstract excerpt

<title>Abstract</title> <p>Forkhead box O1 (FOXO1) is a key transcription factor that plays an important role in pancreatic β-cell compensation under physiological and pathological conditions and serves as a key regulator of glucose homeostasis. While FOXO1 expression in osteoblasts contributes to glucose maintenance through regulating osteocalcin, interestingly, osteocalcin acts directly on β-cells by regulating...

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Literature Corpus work: f38c16c0-002c-5e4e-965b-a932dd363524
DOI: 10.21203/rs.3.rs-6474216/v1

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