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FoxO1 inhibition promotes differentiation of human embryonic stem cells into insulin producing cells

20 Nov 2017

Abstract excerpt

Insulin-producing cells (IPCs) derived from human embryonic stem cells (hESCs) hold great potential for cell transplantation therapy in diabetes. Tremendous progress has been made in inducing differentiation of hESCs into IPCs in vitro, of which definitive endoderm (DE) protocol mimicking foetal pancreatic development has been widely used. However, immaturity of the obtained IPCs limits their further applications...

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PMID: 29157981
DOI: 10.1016/j.yexcr.2017.11.022

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