Article

Network Analysis Reveals Synergistic Genetic Dependencies for Rational Combination Therapy in Philadelphia Chromosome-like Acute Lymphoblastic Leukemia

2021-01-08

Abstract excerpt

<h4>ABSTRACT</h4> Systems biology approaches can identify critical targets in complex cancer signaling networks to inform therapy combinations and overcome conventional treatment resistance. Herein, we developed a data-driven, network controllability-based approach to identify synergistic key regulator targets in Philadelphia chromosome-like B-acute lymphoblastic leukemia (Ph-like B-ALL), a high-risk leukemia sub...

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Literature Corpus work: f3871ad5-5d4b-598f-a7a3-9d25caa7e3b6
DOI: 10.1101/2021.01.06.425608

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